Increasing Lifespan Is Possible By Inhibiting “Rubicon” And Boosting Autophagy

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Increasing lifespan is something that bothered the scientists for a long time, and, thanks to a new study, the researchers are close to solving this puzzle. According to new research, by inhibiting the so-called “Rubicon” protein factor, autophagy boosts, so increasing lifespan is possible.

Autophagy is an essential biological recycling mechanism since it maintains a balance in any living creature. This process makes it possible for the organisms of animals to degrade damaged cells and postpone the development of cellular stress-related illnesses, including cancer, metabolic syndromes, and neurodegenerative diseases. The new study showed that accelerating autophagy by inhibiting the “Rubicon” protein factor is the key to increase lifespan.

“Rubicon has been linked to inhibition of the autophagic process, and knockout of Rubicon in mice helped to mitigate autophagy-related liver diseases.”Therefore, we suspected that Rubicon might directly affect aging through its interaction with autophagy,” explained Tamotsu Yoshimori from Osaka University.

Increasing Lifespan Is Possible By Inhibiting “Rubicon” And Boosting Autophagy

According to the researchers involved in this new study, high levels of “Rubicon” are present in all the aged tissues of living creatures like worms, flies, and mice. By suppressing Rubicon, the scientists managed to boost the autophagy, which improved several aging-related factors. Autophagy even increased lifespan in worms and flies.

“Our analyses revealed that Rubicon suppression in model organisms led to the reduction of age-associated motor decline, as well as reduction of fibrosis. Importantly, we found that Rubicon suppression enabled aged mice to resist attempts to induce Parkinson’s disease,” also said Shuhei Nakamura, the new study’s leading author.

The recent finding that increasing lifespan is possible by inhibiting “Rubicon” protein factor and boosting autophagy might eventually prove essential in the development of reliable methods to postpone aging and prolong life in humans, as well as in keeping age-related conditions, such as dementia, at bay.


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