New Discovery about the Nervous System Regeneration Is Being Unlocked


Scientists want to answer an essential question about the regeneration of specific anatomical structures. For this purpose, they have conducted a computational model of planarian regeneration. They want to explain how fragments of this planaria could form a tail and which form a head. Using this model and experiment, they have found out that the redistribution of chemical signals sets the direction of nerve fibers. This redistribution of chemical signals is establishing after that the course of the head-to-tail axis.

What Are the Results of the Study Saying?

The results were published in the Journal PLOS with the name Computational Biology. The computational model has the purpose of seeing how the genetic signals can control regeneration. For the computational model, the scientists have used a simulation platform called the Planarian Interface for Modeling Body Organization (PLIMBO). This simulation uses many biological mechanisms that lead to regeneration.

Moreover, the computational model creates an environment with a realistic quantitative simulation of events. Those events are taking place at the molecular, cellular, tissue and organism levels. Using this model they could identify the role played by neurons in regeneration. Also, the neurons are ensuring that morphogens can be distributed to enable the regeneration process.

Though we know that neurons are the one that plays a role in regenerative capacity, the study is trying to reveal that some ordered patterns could change the cell and the way it’s being propagated to tissues and organs. They have found that neural directions guide polarity in regeneration because they contain a system of tracks called microtubules. And with the help of molecular engines, the molecules are transported along those tracks.

Finally, PLIMBO is helping scientists to examine regeneration rigorously. They have the chance to add some information to what they already knew by simulating the role of neurons and morphogens. If the experiments are going to be successful, a better understanding of the process of regeneration will help scientists and doctors about how the tissue, organs are formed, and what body patterns can be disrupted.


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