Peanut Allergy Patch In Development

As with smoking cessation, within a few years, a patch could become the first treatment for peanut allergy. © RegBarc, Wikipedia, cc by its 3.0
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A patch developed by a French biotechnology company has achieved encouraging results, in a study presented at a congress this weekend in Atlanta. However, the benefits must be relativized because of the low number of participants.

In Canada, the most common food allergy in children under one year of age is the egg, followed by milk and groundnut. Milk and eggs are frequently cured over time, unlike peanuts. The latter is also very present in the United States, a major consumer of peanuts. That is why the company DBV Technologies has developed a patch to fight against.

The proposed epidermal patch contains a concentrated extract of peanut protein that diffuses into the epidermis to desensitize the patient. The results of the clinical trials carried out on this patch were presented this weekend at the congress of the American Academy of Allergy, Asthma and Immunology in Atlanta, Georgia.

The Vipes study first sought to determine the correct dosage for the patch (50, 100 or 250 μg). It was applied for 24 hours on the arm of adults and teenagers, or the backs of children (221 patients participated). Over 12 months, there was a 53.6% response to treatment in children aged 6 to 11 years, compared with 19.4% in the placebo group.

Then, a second Olfus-Vipes study followed the patients who received the patch containing the maximum dose of 250 μg. It included 171 patients from the Vipes study, including 18 children aged 6 to 11 years. The company reported that no serious adverse reactions were observed in the three years of the Olfus-Vipes study. Treatment was well followed by patients. The release announced a response rate of 83.3% in children with the patch at 250 μg.

Other food allergies

It should be noted, however, that the editorial staff of France 5 questioned the exact figures of this work in an article published on 6 March. The company responded by stating that the Olfus-Vipes study had 171 patients, including 97 children, of whom 18 were between 6 and 11 years of age. 15 of 18 children (83.3%) responded to treatment. The result, albeit encouraging, was a small number of patients.

For Pierre-Henri Behnamou, CEO of DBV Technologies, which is told AFP: “This is the first desensitization patch and healing to allergy food . The goal is not to eat a packet of peanuts but to reduce the sensitivity enough to avoid a potentially fatal reaction in the event of accidental consumption of peanut in a sauce or dish. ”

This approach could be used in the future for other allergies. According to AFP, the company is also testing a patch on children against allergies to dairy products and a new patch against the allergen egg is in preparation.

Another way to limit the risk of allergy is to have children eat these foods very early. In January, the American Institute of Allergy and Infectious Diseases ( NIAID ) suggested reducing the risk of peanut allergy in infants at risk by giving them four months of food.

Erin VanDyke lives on her family farm and has more than 35 years of hands-on experience with the use of livestock guard dogs for predator control. On their farm, Jan and her family use corgis as herding dogs and have raised Shetland sheep, Fainting goats, Morgan and Trakehner horses, and historic breeds of chickens and turkeys. Erin is also an active beekeeper.


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